Trichostatin D, a New Inducer of Phenotypic Reversion in Transformed Cells.

Abstract

Various oncogenes correlate with tumor phenotypes, which represent transformed morphology, loss of contact inhibition, colony formation in soft agar and tumorigenicity in nude mice. Thus, inducers of phenotypic reversion in oncogene-transformed cells mayact as selective antitumor agents without cytotoxicity. Our screening for such substances resulted in the isolation of trichostatin D (Fig.