Cysteine-Derived <i>S</i>-Protected Oxazolidinones: Potential Chemical Devices for the Preparation of Peptide Thioesters

Abstract

[reaction: see text]. An N-S acyl-transfer-mediated preparation of peptide thioesters using the S-protected oxazolidinone derived from cysteine has been developed and applied to the synthesis of a 32-mer biologically active peptide by native chemical ligation protocols.