GroEL-mediated protein folding proceeds by multiple rounds of binding and release of nonnative forms

Principles that Govern the Folding of Protein Chains

Christian B. Anfinsen · Science · 1973 · 7K citations

Engineering, Protein Assembly, Measurement +11

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

Ming Cheng, F. Ulrich Hartl, Jörg Martin et al. · Nature · 1989 · 952 citations

Mitochondrial Biogenesis, Mitochondrial Function, Biochemistry +9

Proteins as molecular chaperones

John Ellis · Nature · 1987 · 912 citations

Protein Chemistry, Molecular Chaperones, Protein Function +7

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

Jörg Martin, Thomas Langer, Raina Boteva et al. · Nature · 1991 · 858 citations

Protein Chemistry, Chaperonin-mediated Protein Folding, Protein Assembly +9

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

Pil-Jung Kang, Joachim Ostermann, Jeffery Shilling et al. · Nature · 1990 · 758 citations

Protein Function, Mitochondrial Function, Biochemistry +9