Concepedia

Early Folding Intermediates

Early Folding Intermediates is a transient conformational state in the protein folding pathway that emerges during the initial phase of folding, distinguished from other intermediates by its rapid formation and stabilization of local secondary structures preceding global tertiary organization.

368

Publications

29.1K

Citations

1.1K

Authors

339

Institutions

Publications per year

2017–2026

12

Parents

Publications

368

Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR

Heinrich Röder, Gülnur A. Elöve, S. Walter Englander · Nature · 1988 · 824 citations

, , +14

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

Laura S. Itzhaki, Daniel E. Otzen, Alan R. Fersht · Journal of Molecular Biology · 1995 · 747 citations

, , +16

Formation of a Molten Globule Intermediate Early in the Kinetic Folding Pathway of Apomyoglobin

Patricia A. Jennings, Peter E. Wright · Science · 1993 · 733 citations

, , +17

Structural Characterization of a Partly Folded Apomyoglobin Intermediate

Frederick M. Hughson, Peter E. Wright, Robert L. Baldwin · Science · 1990 · 710 citations

, , +16

Evidence for a molten globule state as a general intermediate in protein folding

Oleg B. Ptitsyn, Roger H. Pain, Gennady V. Semisotnov et al. · FEBS Letters · 1990 · 678 citations

, , +15

1–5 of 368

Authors

1.1K

  1. AR
    Alan R. Fersht

    Medical Research Council, United Kingdom

    15 publications · 2K citations

    15

    h-index

  2. JB
    Jayant B. Udgaonkar

    National Centre for Biological Sciences, India

    13 publications · 667 citations

    12

    h-index

  3. RL
    Robert L. Baldwin

    Stanford University, United States

    11 publications · 2K citations

    11

    h-index

  4. HR
    Heinrich Röder

    Fox Chase Cancer Center, United States

    11 publications · 1.9K citations

    11

    h-index

  5. CR
    C. Robert Matthews

    Pennsylvania State University, United States

    10 publications · 454 citations

    10

    h-index

1–5 of 1.1K

Institutions

339

  1. University of Pennsylvania

    Philadelphia, United States

    18 h-index

    50 publications

    8.6K citations

  2. Stanford University

    Stanford, United States

    16 h-index

    41 publications

    7.3K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    13 h-index

    40 publications

    5.1K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    44 publications

    1.8K citations

  5. Institut Pasteur

    Paris, France

    11 h-index

    34 publications

    1.5K citations

  6. Scripps Research Institute

    San Diego, United States

    11 h-index

    36 publications

    5.6K citations

  7. Tata Institute of Fundamental Research

    Mumbai, India

    10 h-index

    25 publications

    982 citations

  8. Fox Chase Cancer Center

    Philadelphia, United States

    10 h-index

    31 publications

    3.2K citations

1–8 of 339

Venues

  1. Journal of Molecular Biology

    JMB · 78 publications · 5.2K citations

    39

    h-index

  2. Biochemistry

    55 publications · 2.7K citations

    32

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 29 publications · 3.5K citations

    26

    h-index

  4. Journal of Biological Chemistry

    JBC · 26 publications · 2.3K citations

    23

    h-index

  5. Protein Science

    PS · 22 publications · 1K citations

    19

    h-index

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