Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARα in high fat diet-induced obese mice

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.4K citations

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Journal of Clinical Investigation · 1994 · 3.5K citations · Full text

Insulin Signaling, Glucose Uptake, Metabolic Syndrome +17

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

Guenther Boden · Diabetes · 1997 · 1.6K citations

Insulin Resistance, Metabolic Syndrome, Obesity +15

Mechanism of free fatty acid-induced insulin resistance in humans.

Michael Roden, Thomas B. Price, Gianluca Perseghin et al. · Journal of Clinical Investigation · 1996 · 1.5K citations · Full text

Healthy Subjects, Insulin Signaling, Metabolic Syndrome +16