Increased expression of CEA and MHC class I in colorectal cancer cell lines exposed to chemotherapy drugs

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

J-Y Douillard, David Cunningham, AD Roth et al. · The Lancet · 2000 · 3.3K citations

Medicine, Oncology, Pharmacology +13

Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer

Leonard B. Saltz, John V. Cox, Charles D. Blanke et al. · New England Journal of Medicine · 2000 · 3K citations · Full text

Medicine, Oncology, Pharmacology +13

Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer

David Cunningham, Seppo Pyrhönen, R.D. James et al. · The Lancet · 1998 · 1.3K citations

Medicine, Oncology, Pharmacotherapy +13

Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer

Philippe Rougier, Eric Van Cutsem, Emilio Bajetta et al. · The Lancet · 1998 · 993 citations

Medicine, Oncology, Pharmacotherapy +15

Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

Kwong-Yok Tsang, S Zaremba, Carol Nieroda et al. · JNCI Journal of the National Cancer Institute · 1995 · 498 citations

Life Sciences, Immunology, Oncology +17