Concepedia

Cloning and Heterologous Expression of the Thioviridamide Biosynthesis Gene Cluster from Streptomyces olivoviridis

Masumi Izawa, Takashi Kawasaki, Yoichi Hayakawa

Applied and Environmental Microbiology · 2013 · 78 citations · 19 references

DOIFull text

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Concepts

Abstract

Thioviridamide is a unique peptide antibiotic containing five thioamide bonds from Streptomyces olivoviridis. Draft genome sequencing revealed a gene (the tvaA gene) encoding the thioviridamide precursor peptide. The thioviridamide biosynthesis gene cluster was identified by heterologous production of thioviridamide in Streptomyces lividans.

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