Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

Herbert D. Soule, J. Vázquez, Anna Long et al. · JNCI Journal of the National Cancer Institute · 1973 · 2.5K citations

Medicine, Cell Biology, Oncology +10

Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol

John J. Schlager, Garth Powis · International Journal of Cancer · 1990 · 264 citations

Life Sciences, Biochemistry, Oncology +12

High levels of expression of the NAD(P)H:Quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin

Thierry Cresteil, Anil K. Jaiswal · Biochemical Pharmacology · 1991 · 201 citations

Life Sciences, Molecular Biology, Oncology +11

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells

Richard J. Knox, Frank Friedlos, Michael Jarman et al. · Biochemical Pharmacology · 1988 · 166 citations

Medicine, Cancer Biology, Oncology +9

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

Richard J. Knox, Marion P. Boland, Frank Friedlos et al. · Biochemical Pharmacology · 1988 · 150 citations

Life Sciences, Biochemistry, Molecular Biology +9