Concepedia

Partial V(D)J Recombination Activity Leads to Omenn Syndrome

Anna Villa, Sandro Santagata, Fabio Bozzi, Silvia Giliani, Annalisa Frattini, Luisa Imberti, Luisa Benerini Gatta, Hans D. Ochs, Klaus Schwarz, Luigi D. Notarangelo,

Cell · 1998 · 462 citations · 63 references

Open access

Concepts

Life SciencesGeneticsMolecular GeneticsHuman GeneticsMedical GeneticsRecombinationGenetic Disease PathologyGenetic DisordersRecombination ProteinsV(d)j RecombinationV(d)j Recombination DefectsV(d)j Recombination MachineryV(d)j Recombination MechanismV(d)j Recombination Regulation

References

63

Somatic generation of antibody diversity

Susumu Tonegawa · Nature · 1983 · 4K citations

Life Sciences, Biotechnology, Immunology +14

Somatic generation of antibody diversity.

PubMed · 1976 · 3.3K citations

Life Sciences, Biotechnology, Immunology +14

Development of T <sub>H</sub> 1 CD4 <sup>+</sup> T Cells Through IL-12 Produced by <i>Listeria</i> -Induced Macrophages

Chyi‐Song Hsieh, S E Macatonia, Catherine S. Tripp et al. · Science · 1993 · 3.1K citations

Life Sciences, Immunology, Microbiology +17

RAG-1-deficient mice have no mature B and T lymphocytes

Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations

Life Sciences, Genetics, Immunology +13

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Life Sciences, Genetics, Immunology +14