Substance P Levels and Neutral Endopeptidase Activity in Acute Burn Wounds and Hypertrophic Scar

Abstract

Increased substance P concentration in hypertrophic scar correlates with histologic findings of increased nerve numbers in hypertrophic scar samples. Decreased neutral endopeptidase enzyme activity in hypertrophic scar may contribute to increased available substance P that may result in an exuberant neuroinflammatory response.