BMJ · 2012 · 114 citations · 12 references
Public HealthBiostatisticsEvidence-based PracticeExperimental DesignClinical TrialsRandomized Comparative TrialsRandomized Controlled TrialsStudy DesignTrial MonitoringEarly Stopping RulesEarly Trial TerminationRetention In Clinical TrialsStopping RulesWithdrawal Of Trial Participants
When interim analyses of randomised trials suggest large beneficial treatment effects, investigators sometimes terminate trials earlier than planned. <b>Gordon H Guyatt and colleagues</b> show how this practice can have far reaching and harmful consequences
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Intensive Insulin Therapy in Critically Ill Patients
Greet Van den Berghe, Pieter Wouters, Frank Weekers et al. · New England Journal of Medicine · 2001 · 10K citations · Full text