The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasone

An endotoxin-induced serum factor that causes necrosis of tumors.

E A Carswell, Lloyd J. Old, Robert Kassel et al. · Proceedings of the National Academy of Sciences · 1975 · 4.5K citations · Full text

Inflammation, Residual Endotoxin, Tumor Necrosis Factor +15

Shock and Tissue Injury Induced by Recombinant Human Cachectin

Kevin J. Tracey, Bruce Beutler, Stephen F. Lowry et al. · Science · 1986 · 2.6K citations

Lung Inflammation, Immunology, Cell Death +18

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

Diane Pennica, Glenn E. Nedwin, Joel S. Hayflick et al. · Nature · 1984 · 1.7K citations

Inflammation, Immunotoxicology, Pathogenesis +9

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

Bruce Beutler, Nadia Krochin, Ian W. Milsark et al. · Science · 1986 · 1.3K citations

Human tumor necrosis factor. Production, purification, and characterization.

Bharat B. Aggarwal, William J. Kohr, P E Hass et al. · Journal of Biological Chemistry · 1985 · 918 citations · Full text