A novel role of minocycline: Attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

Shan Zhu, Irina G. Stavrovskaya, Martin Drozda et al. · Nature · 2002 · 1.1K citations

Life Sciences, Neurology, Neuroscience +14

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

Minghua Chen, Victor Ona, Mingwei Li et al. · Nature Medicine · 2000 · 1.1K citations

Life Sciences, Neurology, Neuroscience +17

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

Juha Yrjänheikki, Tiina Tikka, Riitta Keinänen et al. · Proceedings of the National Academy of Sciences · 1999 · 1K citations

Life Sciences, Neuroscience, Pharmacology +17

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Juha Yrjänheikki, Riitta Keinänen, M. Pellikka et al. · Proceedings of the National Academy of Sciences · 1998 · 996 citations

Medicine, Pharmacology, Molecular Neurobiology +12

Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia

Tiina Tikka, Bernd L. Fiebich, Gundars Goldsteins et al. · Journal of Neuroscience · 2001 · 953 citations · Full text

Medicine, Neurobiology, Neuroscience +16