Advanced Synthesis & Catalysis · 2010 · 143 citations · 48 references
Natural SciencesChemistryMedicinal ChemistryCatalysisAddition ReactionsCatalyst SynthesisConjugation ReactionsAsymmetric Catalyst DesignChiral Catalyst DesignConjugate AdditionEnantioselective CatalysisEnantioselective Catalyst DesignEnantioselective SynthesisMild Reaction Conditions
Abstract A chiral squaramide catalysts‐promoted asymmetric sulfa‐Michael conjugated addition of thiols to trans ‐chalcones is presented. Moderate to excellent yields and high enantioselectivities (up to 99% ee ) were achieved under mild conditions.
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