Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.7K citations

Life Sciences, Genetics, Molecular Biology +17

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Manuel Serrano, Gregory J. Hannon, David Beach · Nature · 1993 · 3.7K citations

Life Sciences, Cell Biology, Molecular Biology +17

A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

Brian G.M. Durie, Sydney E. Salmon · Cancer · 1975 · 3.1K citations

Medicine, Hematology, Oncology +15

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

Alexander Kamb, Nelleke A. Gruis, Jane Weaver-Feldhaus et al. · Science · 1994 · 2.8K citations

Life Sciences, Genetics, Molecular Genetics +17

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Adrian Merlo, James G. Herman, Li Mao et al. · Nature Medicine · 1995 · 2K citations

Medicine, Genetics, Molecular Biology +17