Science · 1969 · 59 citations · 10 references
MedicineBiochemistryPharmacologyAlcohol ToxicologyBiochemical PharmacologyDrug MetabolismAlcohol MetabolismAlcohol PharmacologyAlcohol MetabolitesAlcohol OxidationHepatic Alcohol MetabolismHepatic OxidationMicrosomal Drug MetabolismOxidationPhenobarbital TherapyPhenobarbital Use
A role for microsomal alcohol oxidation cannot be demonstrated in vivo. Factors affecting microsomal drug hydroxylations had no effect on alcohol metabolism in the rat in vivo. The compound SKF 525-A which inhibits, and chronic phenobarbital treatment which enhances microsomal drug hydroxylations did not alter alcohol oxidation.
10
The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen.
Gillette, Brodie Bb, La Du Bn · PubMed · 1957 · 401 citations
Medicine, Biochemistry, Pharmacology +16