Does a targeting ligand influence nanoparticle tumor localization or uptake?

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Formulation of functionalized PLGA–PEG nanoparticles for in vivo targeted drug delivery

Jianjun Cheng, Benjamin A. Teply, Ines Sherifi et al. · Biomaterials · 2006 · 1.3K citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +14

Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models

Dmitri B. Kirpotin, Daryl C. Drummond, Yi Shao et al. · Cancer Research · 2006 · 1.1K citations · Full text

Pharmacy, Cancer Biology, Molecular Pharmaceutics +17

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality <i>in vivo</i> imaging

Derek W. Bartlett, Helen C. Su, Isabel J. Hildebrandt et al. · Proceedings of the National Academy of Sciences · 2007 · 797 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size

Chao Fang, Bin Shi, Yuanying Pei et al. · European Journal of Pharmaceutical Sciences · 2005 · 422 citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17