The effect of oils on the lymphatic absorption of DDT

Abstract

Plasma concentrations of DDT were measured in conscious rats following oral administration in arachis oil, Miglyol 812 (fractionated coconut oil), liquid paraffin or as a fine suspension in water. The total absorption of DDT, calculated as the area under the plasma concentration time curve, was significantly greater for the arachis oil formulation compared to the other vehicles. In anaesthetized rats it was shown that DDT absorption was almost totally via the lymphatic system, and that lymph levels of DDT were highest following administration in arachis oil. Measurement of lymph flow showed that this enhanced absorption of DDT in the presence of arachis oil was not due to an increased flow as both arachis oil and liquid paraffin stimulated lymph production to the same extent.