Modifications and structure–activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations

Medicine, Vascular Pharmacology, Physiology +6

Cloning and expression of a cDNA encoding an endothelin receptor

Hiroshi Arai, Seiji Hori, Ichiro Aramori et al. · Nature · 1990 · 2.6K citations

Signal Transduction, Molecular Physiology, Physiology +10

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

Takeshi Sakurai, Masashi Yanagisawa, Yoh Takuwat et al. · Nature · 1990 · 2.4K citations

Molecular Pharmacology, Signal Transduction, Molecular Physiology +11

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

Martine Clozel, Volker Breu, Gillian A. Gray et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 667 citations

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Martine Clozel, Volker Breu, Kaspar F. Burri et al. · Nature · 1993 · 529 citations

Medicine, Vascular Pharmacology, Physiology +5