Notoginsenoside R1 Attenuates Atherosclerotic Lesions in ApoE Deficient Mouse Model

Abstract

Collectively, our results demonstrated for the first time the anti-atherosclerotic effects of NR1, which could be in part mediated through its multiple targeting effects on inflammation, oxidative stress, lipid metabolism and microRNA expression. These results therefore justify further evaluation of NR1 as a therapeutic agent treating atherosclerosis.