Concepedia

CDK inhibitors in cancer therapy: what is next?

Marcos Malumbres, Paolo Pevarello, Mariano Barbacid, James R. Bischoff

Trends in Pharmacological Sciences · 2007 · 240 citations · 28 references

DOI

Concepts

References

28

Cdk1 is sufficient to drive the mammalian cell cycle

David Santamarı́a, Cédric Barrière, Antonio Cerqueira et al. · Nature · 2007 · 1.1K citations

, , +12

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

Sagrario Ortega, Ignacio Priéto, Junko Odajima et al. · Nature Genetics · 2003 · 793 citations

, , +14

Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6

Marcos Malumbres, Rocı́o Sotillo, David Santamarı́a et al. · Cell · 2004 · 788 citations · Full text

, , +12

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

Sushil G. Rane, Pierre Dubus, Richard V. Mettus et al. · Nature Genetics · 1999 · 699 citations

, , +17

Cdk2 Knockout Mice Are Viable

Cyril Berthet, Eiman Aleem, Vincenzo Coppola et al. · Current Biology · 2003 · 657 citations · Full text

, , +5