Stimulation of prolactin release in the rat by intraventricular injection of β-end orphin and methionine-enkephalin

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications

Clyde Young Kramer · Biometrics · 1956 · 3.1K citations

Public Health, Biostatistics, Experimental Design +9

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14

Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness

Floyd E. Bloom, David J. Segal, Nicholas Ling et al. · Science · 1976 · 812 citations

Medicine, Neuroscience, Pharmacology +17

Analgesia induced in vivo by central administration of enkephalin in rat

James D. Belluzzi, Norman H. Grant, Victor M. Garsky et al. · Nature · 1976 · 528 citations

Medicine, Pharmacology, Neuropharmacology +11