Publication | Open Access
Differential Gene and MicroRNA Expression between Etoposide Resistant and Etoposide Sensitive MCF7 Breast Cancer Cell Lines
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Citations
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References
2012
Year
Breast OncologyCancer BiologyAbc Transporter GenesCellular PhysiologyTumor BiologyDrug ResistanceDifferential GeneResistance Mutation (Virology)Etoposide Resistance OperatingRadiation OncologyAntimicrobial ResistanceCancer ResearchHealth SciencesEtoposide ResistantDrug Resistance AnalysisMicrorna ExpressionGene ExpressionPharmacologyCell BiologyMicrorna DetectionAntimicrobial Resistance GeneCancer GenomicsBreast CancerTumor SuppressorSystems BiologyMedicine
In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.
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