Over‐Expression of Cofilin‐1 and Phosphoglycerate Kinase 1 in Astrocytomas Involved in Pathogenesis of Radioresistance

Abstract

The results indicated cofilin-1 enhances the motility of tumor cells which is important invasive potential of malignancy. PGK1 is metabolic enzyme and seems to be correlated with the negative prognosis following radiotherapy. Thus, cofilin-1 and PGK1 might be involved in the radioresistant phenotype and are potential biomarkers for developing better therapeutic methods.