Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

Norman E. Sharpless, Nabeel Bardeesy, Kee-Ho Lee et al. · Nature · 2001 · 850 citations

Medicine, Molecular Genetics, Oncology +12

Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus

David F. Stojdl, Brian D. Lichty, Shane Knowles et al. · Nature Medicine · 2000 · 816 citations

Life Sciences, Molecular Biology, Oncology +16

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

Keisuke Ueki, Yasuhiro Ono, John W. Henson et al. · PubMed · 1996 · 408 citations

Medicine, Genetics, Oncology +17

Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes.

J. Andrea McCart, Jerrold M. Ward, Yun Hu et al. · PubMed · 2001 · 362 citations

Life Sciences, Cancer Biology, Oncology +17

Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses

Keiro Ikeda, Tomotsugu Ichikawa, Hiroaki Wakimoto et al. · Nature Medicine · 1999 · 342 citations

Medicine, Neuroscience, Oncology +16