Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia☆

Effective targeted gene ‘knockdown’ in zebrafish

Aidas Nasevicius, Stephen C. Ekker · Nature Genetics · 2000 · 2.5K citations

Developmental Biology, Genetics, Genetic Engineering +4

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Cardiac Muscle, Cardiomyopathy, Molecular Physiology +10

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

Mark Curran, Igor Splawski, Katherine W. Timothy et al. · Cell · 1995 · 2.3K citations · Full text

Long Qt Syndrome, Cardiomyopathy, Genetics +9

A structural basis for drug-induced long QT syndrome

John S. Mitcheson, Jun Chen, Monica Lin et al. · Proceedings of the National Academy of Sciences · 2000 · 929 citations · Full text

Cardiac Muscle, Channelopathies, Cardiomyopathy +11

The Zebrafish Book : A Guide for the Laboratory Use of Zebrafish

Monte Westerfield · Medical Entomology and Zoology · 2000 · 784 citations

Biology, Animal Testing, Developmental Biology +6