The synthesis of mevinic acids

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Alfred W. Alberts, J Chen, G. W. Kuron et al. · Proceedings of the National Academy of Sciences · 1980 · 1.6K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

M S Brown, J L Goldstein · Journal of Lipid Research · 1980 · 1.2K citations · Full text

Life Sciences, Biochemistry, Microbiology +16

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

Akira Endo, Masao Kuroda, Yoshio Tsujita · The Journal of Antibiotics · 1976 · 954 citations · Full text

Life Sciences, Microbiology, Drug Discovery +2

Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds

Mary A. Blanchette, William Choy, Jeffery T. Davis et al. · Tetrahedron Letters · 1984 · 910 citations

Natural Sciences, Chemistry, Inorganic Chemistry +1

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

Akira Endo, Masao Kuroda, Kazuhiko Tanzawa · FEBS Letters · 1976 · 802 citations

Life Sciences, Biochemistry, Pharmacology +16