Preparation of nanoparticles composed of poly(γ-glutamic acid)-poly(lactide) block copolymers and evaluation of their uptake by HepG2 cells

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption

Ruxandra Gref, Martín Luck, P. Quellec et al. · Colloids and Surfaces B Biointerfaces · 2000 · 1.7K citations

Natural Sciences, Materials Engineering, Materials Science +17

Tumoritropic and lymphotropic principles of macromolecular drugs.

Hiroshi Maeda, Yasuhiro Matsumura · PubMed · 1989 · 580 citations

Pharmacy, Pharmaceutics, Pharmacology +16

Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes

David C. Litzinger, A. M. J. Buiting, Nico van Rooijen et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1994 · 544 citations

Pharmacy, Biophysics, Pharmacokinetics +17

Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs

Yuancai Dong, Si-Shen Feng · Biomaterials · 2003 · 455 citations

Pharmacy, Oncology, Pharmaceutics +17