Transgenic mice expressing the βAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Sharon Pellow, Philippe Chopin, Sandra E. File et al. · Journal of Neuroscience Methods · 1985 · 5.8K citations

Social Sciences, Behavioral Sciences, Psychology +9

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations

Life Sciences, Neurobiology, Neuroscience +17

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

Life Sciences, Neuroscience, Pathology +16

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

Fiona Crawford, Karin Axelman, Henry Houlden et al. · Nature Genetics · 1992 · 1.5K citations

Life Sciences, Neurology, Neuroscience +17

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Leigh A. Holcomb, Marcia N. Gordon, Eileen McGowan et al. · Nature Medicine · 1998 · 1.4K citations

Life Sciences, Neurology, Neuroscience +17