Pioglitazone time-dependently reduces tumour necrosis factor-α level in muscle and improves metabolic abnormalities in Wistar fatty rats

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Jürgen M. Lehmann, Linda B. Moore, Tracey Smith-Oliver et al. · Journal of Biological Chemistry · 1995 · 3.6K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations

Life Sciences, Endocrinology, Molecular Biology +17

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

Philip A. Kern, Mehrnoosh Saghizadeh, Juling Ong et al. · Journal of Clinical Investigation · 1995 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Physiology +10

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

Robert Frederich, Bettina Löllmann, A. Hamann et al. · Journal of Clinical Investigation · 1995 · 562 citations · Full text

Life Sciences, Endocrinology, Physiology +14