Trifluoromethyl group as a pharmacophore: Effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand

DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival

Holger M. Reichardt, Klaus H. Kaestner, Jan Tuckermann et al. · Cell · 1998 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Randy K. Bledsoe, Valerie G. Montana, Thomas B. Stanley et al. · Cell · 2002 · 815 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP‐1.

Susanne Heck, Michael Kullmann, Andreas Gast et al. · The EMBO Journal · 1994 · 529 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Heike Schäcke, Arndt Schottelius, Wolf‐Dietrich Döcke et al. · Proceedings of the National Academy of Sciences · 2003 · 470 citations · Full text

Life Sciences, Pharmacology, Pharmacotherapy +15

The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain

Björn Kauppi, Clarissa G. Jakob, Mathias Färnegårdh et al. · Journal of Biological Chemistry · 2003 · 338 citations · Full text

Medicine, Biochemistry, Pharmacology +17