Concepedia

Phase I study of the MEK inhibitor trametinib in combination with the AKT inhibitor afuresertib in patients with solid tumors and multiple myeloma

Anthony W. Tolcher, Amita Patnaik, Kyriakos P. Papadopoulos, Drew Rasco, Carlos Becerra, Alicia J. Allred, Keith Orford, Gursel Aktan, Geraldine Ferron‐Brady, Nageatte Ibrahim,

Cancer Chemotherapy and Pharmacology · 2014 · 158 citations · 10 references

DOI

Concepts

References

10

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

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Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma

Keith T. Flaherty, Caroline Robert, Peter Hersey et al. · New England Journal of Medicine · 2012 · 2.1K citations · Full text

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Improved survival with MEK Inhibition in BRAF-mutated melanoma for the METRIC Study Group

Keith T. Flaherty, Caroline Robert, Peter Hersey et al. · Zurich Open Repository and Archive (University of Zurich) · 2012 · 1.3K citations

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice L. Horn et al. · Nature · 2007 · 1.3K citations

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The PTEN–PI3K pathway: of feedbacks and cross-talks

Arkaitz Carracedo, Pier Paolo Pandolfi · Oncogene · 2008 · 893 citations

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