Effects of the changes in enzyme activities on metabolic flux redistribution around the 2-oxoglutarate branch in glutamate production by Corynebacterium glutamicum

Metabolic flux distributions in <i>Corynebacterium glutamicum</i> during growth and lysine overproduction

Joseph J. Vallino, Gregory Stephanopoulos · Biotechnology and Bioengineering · 1993 · 515 citations

Life Sciences, Biochemistry, Microbiology +17

Determination of the fluxes in the central metabolism ofCorynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing

Achim Marx, Albert A. de Graaf, Wolfgang Wiechert et al. · Biotechnology and Bioengineering · 1996 · 406 citations

Life Sciences, Biochemistry, Microbiology +15

Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates

R. T. J. M. van der Heijden, Joseph J. Heijnen, C. Hellinga et al. · Biotechnology and Bioengineering · 1994 · 197 citations

Natural Sciences, Chemical Engineering, Chemistry +17

Responses of metabolic systems to large changes in enzyme activities and effectors

J. Rankin SMALL, H. Kacser · European Journal of Biochemistry · 1993 · 163 citations

Life Sciences, Biochemistry, Biological Systems Modeling +15

Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross errors

R. T. J. M. van der Heijden, B. Romein, Joseph J. Heijnen et al. · Biotechnology and Bioengineering · 1994 · 156 citations

Life Sciences, Biochemistry, Chemical Engineering +13