A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature · 1997 · 2.9K citations

Life Sciences, Biochemistry, Cell Biology +16

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Yuan Gao, J. Bradley Dickerson, Fukun Guo et al. · Proceedings of the National Academy of Sciences · 2004 · 1.1K citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Piero Crespo, Kornel E. Schuebel, Amy A. Ostrom et al. · Nature · 1997 · 757 citations

Life Sciences, Biochemistry, Molecular Biology +12

Selective Inhibition of <i>ras</i> -Dependent Transformation by a Farnesyltransferase Inhibitor

Nancy E. Kohl, Scott D. Mosser, S. J. DESOLMS et al. · Science · 1993 · 582 citations

Medicine, Oncology, Pharmacology +13

A role for Rac in Tiaml-induced membrane ruffling and invasion

Frits Michiels, Gaston Habets, Jord C. Stam et al. · Nature · 1995 · 555 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10