Expression of the Rho‐family GTPase gene <i>RHOF</i> in lymphocyte subsets and malignant lymphomas

Abstract

Summary We have studied the expression of RHOF , a member of the Rho‐GTPase family, in an array of lymphoid cells and tissues. Previous microarray studies demonstrated RHOF upregulation in a subset of transformed follicular lymphomas. Real‐time quantitative polymerase chain reaction evaluated RHOF expression in lymphocyte subpopulations, and normal and malignant lymphoid tissue. Cells and tissues of B‐cell origin expressed higher RHOF levels than their T‐cell counterparts. Neoplastic cells and tissues of B‐cell origin expressed higher levels of RHOF than their benign cellular counterparts. Relatively elevated levels of RHOF were seen in lymphomas derived from germinal centre origin.