Retinal degeneration characterizes a spinocerebellar ataxia mapping to chromosome 3p

Launce Gouw, Craig D. Kaplan, John H. Haines, +6

Nature Genetics

Molecular NeuroscienceRetinaOphthalmologyGenetic DisorderMendelian Disorder +7

Autosomal dominant cerebellar ataxia with retinal degeneration

Launce Gouw, Kathleen B. Digre, Cheryl P. Harris, +2

Neurology

GeneticsDisease Gene IdentificationGenetic AnalysisRetinaMendelian Disorder +14

Sodium channel mutations in paramyotonia congenita and hyperkalemic periodic paralysis

Louis J. Ptacek, Launce Gouw, Hubert Kwieciński, +7

Annals of Neurology

ChannelopathiesSodium Channel StructureMolecular PhysiologyPeriodic ParalysesMuscle Function +12

Analysis of the dynamic mutation in the SCA7 gene shows marked parental effects on CAG repeat transmission

Launce Gouw

Human Molecular Genetics

Repeat LengthsGeneticsGenomic MechanismPathologyMolecular Genetics +17

Proteolytic Cleavage of Ataxin-7 by Caspase-7 Modulates Cellular Toxicity and Transcriptional Dysregulation

Jessica E. Young, Launce Gouw, Stephanie Propp, +12

Journal of Biological Chemistry

Retinal NeuronsAtaxin-7 ProteinSca7 Disease PathogenesisApoptosisImmunology +17

Is There a Predisposition Gene for Ewing's Sarcoma?

R. Lor Randall, Stephen L. Lessnick, Kevin B. Jones, +4

Journal of Oncology

Predisposition GeneSarcoma DevelopmentTumoral PathologySomatic VariantCancer Pathology +11

Exploiting antitumor immunity to overcome relapse and improve remission duration

Lei L. Chen, Xinjian Chen, Haesun Choi, +26

Cancer Immunology Immunotherapy

Cell TherapyImmunologyImmune RegulationImmunoeditingImmunotherapeutics +20

Investigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: Phase 1 dose-escalation study

Gerald S. Falchook, Razelle Kurzrock, Launce Gouw, +6

Investigational New Drugs

Dose-escalation StudyNon-hematologic MalignanciesEnteric-coated Tablet FormulationMedicineMalignant Blood Disorder +6

Expression of the Rho‐family GTPase gene <i>RHOF</i> in lymphocyte subsets and malignant lymphomas

Launce Gouw, N. Scott Reading, Stephen D. Jenson, +2

British Journal of Haematology

Lymphocyte DevelopmentImmunologyPathologyMalignant LymphomasHigher Rhof Levels +17

Phase Ib study of RG7112 with doxorubicin (D) in advanced soft tissue sarcoma (ASTS).

Sant P. Chawla, Jean‐Yves Blay, Antoîne Italiano, +14

Journal of Clinical Oncology

ImmunologyPathologyPharmacotherapyTumor BiologyPre-clinical Pharmacology +14