Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Takeshi Nishikawa, Diane Edelstein, Xue Du et al. · Nature · 2000 · 4.3K citations

Life Sciences, Biochemistry, Physiology +14

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Kathy K. Griendling, C A Minieri, Jeremy D. Ollerenshaw et al. · Circulation Research · 1994 · 2.7K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial

Stevo Julius, Sverre E. Kjeldsen, Michael A. Weber et al. · The Lancet · 2004 · 2.5K citations

Medicine, Pharmacology, Pharmacotherapy +13

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

Toyoshi Inoguchi, Pan Li, F. Umeda et al. · Diabetes · 2000 · 1.6K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

Hideaki Kaneto, Yoshitaka Kajimoto, J Miyagawa et al. · Diabetes · 1999 · 713 citations

Medicine, Biochemistry, Endocrinology +16