Chronic Stress Induces Anxiety via an Amygdalar Intracellular Cascade that Impairs Endocannabinoid Signaling

The endogenous cannabinoid system controls extinction of aversive memories

Giovanni Marsicano, Carsten T. Wotjak, Shahnaz Christina Azad et al. · Nature · 2002 · 1.7K citations

Cannabis Use, Cognitive Science, Addiction +7

Modulation of anxiety through blockade of anandamide hydrolysis

Satish Kathuria, Silvana Gaetani, Darren Fegley et al. · Nature Medicine · 2002 · 1.3K citations

Anandamide Hydrolysis, Psychoactive Drug, Psychiatry +6

Disrupted Amygdalar Subregion Functional Connectivity and Evidence of a Compensatory Network in Generalized Anxiety Disorder

Amit Etkin, Katherine E. Prater, Alan F. Schatzberg et al. · Archives of General Psychiatry · 2009 · 672 citations

Endocannabinoid Signaling Negatively Modulates Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis

Sachin Patel, Craig T. Roelke, David J. Rademacher et al. · Endocrinology · 2004 · 468 citations

Cannabis Use, Stress Hormone, Neurophysiology +15

Mental disorders among persons with heart disease — results from World Mental Health surveys

Johan Ormel, Michael Von Korff, Huibert Burger et al. · General Hospital Psychiatry · 2007 · 351 citations · Full text

Mental Disorders, Mental Health Services, Psychological Co-morbidities +11