Levetiracetam in children with refractory epilepsy: Lack of correlation between plasma concentration and efficacy

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

Berkley A. Lynch, Nathalie Lambeng, Karl Nocka et al. · Proceedings of the National Academy of Sciences · 2004 · 1.6K citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy

Henrik Klitgaard, Alain Matagne, J.G. Gobert et al. · European Journal of Pharmacology · 1998 · 509 citations

Medicine, Neuroscience, Pharmacology +12

Efficacy and Safety of Levetiracetam in Children with Partial Seizures: An Open‐label Trial

Tracy A. Glauser, John M. Pellock, E. Martina Bebin et al. · Epilepsia · 2002 · 159 citations

Medicine, Pharmacology, Pharmacotherapy +17

Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein

Michel Gillard, Pierre Chatelain, B. B. Fuks · European Journal of Pharmacology · 2006 · 146 citations

Life Sciences, Neuroscience, Pharmacology +12

Intracellular Calcium Increase in Epileptiform Activity: Modulation by Levetiracetam and Lamotrigine

Antonio Pisani, Paola Bonsi, Giuseppina Martella et al. · Epilepsia · 2004 · 135 citations

Medicine, Neuroscience, Pharmacology +15