Intracellular Calcium Increase in Epileptiform Activity: Modulation by Levetiracetam and Lamotrigine

Abstract

These results demonstrate that large, transient elevations in neuronal [Ca2+]i correlate to epileptiform discharges. The antagonistic effects of LEV and LTG on [Ca2+]i overload might represent the basis for their anticonvulsant efficacy and could preserve neuronal viability.