A novel t(4;22)(q31;q12) produces an EWSR1–SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

Olivier Delattre, Jessica Zucman‐Rossi, Béatrice Plougastel-Douglas et al. · Nature · 1992 · 1.9K citations

Life Sciences, Genetics, Molecular Genetics +17

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

Win May, Mikhail L. Gishizky, Stephen L. Lessnick et al. · Proceedings of the National Academy of Sciences · 1993 · 577 citations

Medicine, Molecular Biology, Oncology +17

Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

Thomas Melot, Chantal Desmaze, Jacques Ghysdael et al. · The EMBO Journal · 1993 · 539 citations · Full text

Medicine, Molecular Biology, Oncology +15

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.

Win May, Stephen L. Lessnick, Benjamin S. Braun et al. · Molecular and Cellular Biology · 1993 · 498 citations · Full text

Medicine, Molecular Biology, Oncology +16

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.

In Sang Jeon, Jaimie N. Davis, Benjamin S. Braun et al. · PubMed · 1995 · 477 citations

Medicine, Genetics, Molecular Genetics +12