Induction of a secondary human anti‐HLA alloimmune response in severe combined immunodeficient mice engrafted with human lymphocytes

Abstract

Hu-PBL-SCID mice are a useful model system in which to study and manipulate the induction of secondary human alloimmune responses against cellular HLA class I antigens. This model will be valuable for testing the in vivo effect of novel immunotherapies on the inhibition of the human alloantibody response.