Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines

The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells

Richard Kowalski, Paraskevi Giannakakou, Sarath P. Gunasekera et al. · Molecular Pharmacology · 1997 · 262 citations

Medicine, Oncology, Pharmacology +17

Nortopsentins A, B, and C. Cytotoxic and antifungal imidazolediylbis[indoles] from the sponge Spongosorites ruetzleri

Shinichi Sakemi, Hao Sun · The Journal of Organic Chemistry · 1991 · 196 citations

Life Sciences, Marine Biology, Medicinal Chemistry +13

Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies

Shinji Tsujii, Kenneth L. Rinehart, Sarath P. Gunasekera et al. · The Journal of Organic Chemistry · 1988 · 154 citations

Life Sciences, Marine Biology, Medicinal Chemistry +17

Topsentins, new toxic bis-indole alkaloids from the marine sponge <i>Topsentia</i><i>genitrix</i>

Kristin Bartik, J. C. Braekman, D. Daloze et al. · Canadian Journal of Chemistry · 1987 · 110 citations · Full text

Natural Sciences, Marine Biology, Toxicology +14

The Seco-Taxane IDN5390 Is Able to Target Class III β-Tubulin and to Overcome Paclitaxel Resistance

Cristiano Ferlini, Giuseppina Raspaglio, Simona Mozzetti et al. · Cancer Research · 2005 · 105 citations · Full text

Medicine, Oncology, Pharmacology +15