Interspecies comparison of carcinogenic potency

Abstract

For guidance in decisions on how to safeguard humans from carcinogens, it is necessary to use data on carcinogenesis in animals. This paper disucsses how such data, combined with human experience, may be used quantitatively in such decisions. It is demonstrated empirically that good correlations exist between different species for suitably defined carcinogenic potencies for various chemicals. This allows sufficient accuracy in extrapolating form animal data to human risk to support a logical scheme for the evaluation of such risks. Some recommendations for future research are given.