New Principles in Medicinal Organometallic Chemistry

Abstract

Hard-core drugs: Recent structural and spectroscopic studies demonstrate the versatility of organometallic drug candidates, for example, as novel protein kinase inhibitors and hormone-independent breast cancer prodrugs. The presence of a transition-metal center in such systems allows both the organization of ligands in 3D space (see picture) and the control of redox-activation processes in biological systems.