Concepedia

Ketamine inhibits tumor necrosis factor-α and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation

Gone-Jhe Wu, Ta-Liang Chen, Yune‐Fang Ueng, Ruei‐Ming Chen

Toxicology and Applied Pharmacology · 2007 · 107 citations · 28 references

DOI

Concepts

References

28

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

, , +15

Ketamine—Its Pharmacology and Therapeutic Uses

Paul F. White, Walter L. Way, Anthony J. Trevor · Anesthesiology · 1982 · 1.5K citations · Full text

, , +16

Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

Carl Nathan · Journal of Clinical Investigation · 1987 · 806 citations · Full text

, , +10

Toll–Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells

Yong‐Han Paik, Robert F. Schwabe, Ramón Bataller et al. · Hepatology · 2003 · 645 citations · Full text

, , +17

Suppression of Natural Killer Cell Activity and Promotion of Tumor Metastasis by Ketamine, Thiopental, and Halothane, but Not by Propofol: Mediating Mechanisms and Prophylactic Measures

Rivka Melamed, Shahar Bar-Yosef, Guy Shakhar et al. · Anesthesia & Analgesia · 2003 · 455 citations

, , +15