Concepedia

Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT

Christopher R. Garrett, Domenico Coppola, Robert M. Wenham, Christopher Cubitt, Anthony Neuger, Timothy J. Frost, Richard M. Lush, Daniel M. Sullivan, Jin Q. Cheng, Saı̈d M. Sebti

Investigational New Drugs · 2010 · 80 citations · 22 references

DOI

Concepts

References

22

A Retroviral Oncogene, <i>akt</i> , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

Alfonso Bellacosa, Joseph R. Testa, Stephen Staal et al. · Science · 1991 · 885 citations

, , +17

Molecular alterations of the <i>AKT</i>2 oncogene in ovarian and breast carcinomas

Alfonso Bellacosa, Daniela de Feo, Andrew K. Godwin et al. · International Journal of Cancer · 1995 · 836 citations

, , +14

AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

Mei Sun, Gen Wang, June E. Paciga et al. · American Journal Of Pathology · 2001 · 452 citations · Full text

, , +17

Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

Lin Yang, Han C. Dan, Mei Sun et al. · Cancer Research · 2004 · 423 citations

, , +17

Akt Blocks Breast Cancer Cell Motility and Invasion through the Transcription Factor NFAT

Merav Yoeli-Lerner, Gary K. Yiu, Isaac Rabinovitz et al. · Molecular Cell · 2005 · 403 citations · Full text

, , +12