Mechanical force augments the anti‐osteoclastogenic potential of human gingival fibroblasts <i>in vitro</i>

Abstract

Application of centrifugal force to human gingival fibroblasts accelerates osteoprotegerin production by these cells, which stimulates the potential of human gingival fibroblasts to suppress osteoclastogenesis. Overall, human gingival fibroblasts might have natural defensive mechanisms to inhibit bone resorption induced by a mechanical stress.