Periodontal Ligament Cells Under Mechanical Stress Induce Osteoclastogenesis by Receptor Activator of Nuclear Factor κB Ligand Up-Regulation via Prostaglandin E2 Synthesis

Hiroyuki Kanzaki, Mirei Chiba, Yoshinobu Shimizu, +1

Journal of Bone and Mineral Research

EngineeringOsteoporosisPge2 TreatmentOrthopaedic SurgeryInflammation +17

Dual Regulation of Osteoclast Differentiation by Periodontal Ligament Cells through RANKL Stimulation and OPG Inhibition

Hiroyuki Kanzaki, Mirei Chiba, Yoshimi Shimizu, +1

Journal of Dental Research

The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling

Hiroyuki Kanzaki, Fumiaki Shinohara, Mikihito Kajiya, +1

Journal of Biological Chemistry

Lipid PeroxidationCell DeathReactive Oxygen SpeciesCell Death MechanismsOsteoporosis +19

Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement

Hiroyuki Kanzaki, Masatoshi Chiba, K. Arai, +4

Gene Therapy

MechanobiologyDevelopmental BiologyPeriodontal TissueGeneticsOral Biology +7

Local OPG Gene Transfer to Periodontal Tissue Inhibits Orthodontic Tooth Movement

Hiroyuki Kanzaki, Masatoshi Chiba, Ichiro Takahashi, +3

Journal of Dental Research

MechanobiologyOrthodontic TreatmentDental ConditionsDevelopmental BiologyBone Morphogenic Protein +13

Cyclical Tensile Force on Periodontal Ligament Cells Inhibits Osteoclastogenesis through OPG Induction

Hiroyuki Kanzaki, Masatoshi Chiba, Akiko Satô, +4

Journal of Dental Research

Tissue EngineeringOpg InductionEngineeringBiomedical EngineeringOsteoporosis +16

Soluble RANKL Cleaved from Activated Lymphocytes by TNF-α–Converting Enzyme Contributes to Osteoclastogenesis in Periodontitis

Hiroyuki Kanzaki, Seicho Makihira, M. Suzuki, +8

The Journal of Immunology

RANKL induces Bach1 nuclear import and attenuates Nrf2‐mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice

Hiroyuki Kanzaki, Fumiaki Shinohara, Kanako Itohiya, +7

The FASEB Journal

Redox SignalingTranscriptional RegulationSignal TransductionMedicineGene Expression +11

Dimethyl fumarate inhibits osteoclasts <i>via</i> attenuation of reactive oxygen species signalling by augmented antioxidation

Yuuki Yamaguchi, Hiroyuki Kanzaki, Yuta Katsumata, +6

Journal of Cellular and Molecular Medicine

Augmented AntioxidationCell DeathLocal Dmf InjectionAntioxidant EnzymesReactive Oxygen Species +17

Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement

Ningning Zhao, Jiuxiang Lin, Hiroyuki Kanzaki, +4

American Journal of Orthodontics and Dentofacial Orthopedics

SclerostinDevelopmental BiologyBone Morphogenic ProteinGeneticsOrthodontic Research +5