Synthesis, reactions and biological evaluation of some 1,2,4‐triazine derivatives

Abstract

Abstract 6‐Substituted benzyl‐4‐phenyl‐3‐thioxo‐2,3,4,5‐tetrahydro‐1,2,4‐triazin‐5‐ones 3a‐d were prepared and converted into their corresponding 3‐methylthio derivatives 4a‐d . Reaction of compounds 4a‐d with hydrazine hydrate gave the corresponding 4‐amino‐3‐anilino‐4,5‐dihydro‐1,2,4‐triazin‐5‐ones 5a‐d . 6‐Substituted benzyl‐4‐phenyl‐2,3,4,5‐tetrahydro‐1,2,4‐triazin‐3,5‐diones 9a‐c were synthesized and allowed to react with hydrazine hydrate to give the corresponding 6‐substituted benzyl‐4‐amino‐2,3,4,5‐tetrahydro‐1,2,4‐triazin‐3,5‐diones 10a‐c . The biological evaluation of some of these triazines is described. All compounds were screened for antiviral, antibacterial, antimycobacterial, antifungal and antiyeast activity. No important biological activity was found.